Spotlight on Pathogen Control with ProVent® ECL, Strateris®, and Novela® ECL
This year, we grew our PathKinex™ pathogen libraries to over 21,000 isolates! Our multi-strain ECL product formulations provide multiple layers of coverage against these pathogen isolates. In fact, in samples tested between 2018 and 2024, ECL products showed over 90% coverage against E. coli, Clostridium perfringens, and Salmonella.
ProVent® ECL Inhibited
Novela® ECL Inhibited
Strateris® Inhibited
Coccidia Explained
Coccidia are common members of microbial coinfections, and while coccidiosis is an important concern in poultry, it can also impact ruminants and swine with subclinical infections. The PathKinex™ panel already includes multiple coccidia targets, such as Eimeria bovis for dairy and three Eimeria species for poultry, but as of this year, an assay for Isospora suis is now validated for swine.
United Animal Health DFMs: Comprehensive Support During Pathogen Challenges
Bacillus are highly effective against pathogens in a multitude of ways. Our Bacillus can help inhibit the formation of protective biofilms produced by pathogens, and they can disrupt the quorum-sensing (cell-to-cell communication) between pathogens, which could help reduce pathogenicity.
PathKinex™ AST in Action!
In April, we presented the PathKinex™ platform’s antimicrobial susceptibility testing (AST) through a time-lapse video. AST assesses the growth of pathogens of interest in the presence of Bacillus fermentate, which contains various types of antimicrobial molecules. During testing, control wells become cloudy with strong pathogen growth, while Bacillus strain fermentate wells are more transparent, indicating pathogen inhibition.
Influencing Immune Response: How Our Bacillus Strains Can Play a Role
Individual Bacillus strains have differing capacities to influence the immune system. The immunostimulatory activity of our health-focused Bacillus strains at higher dosages suggests they can help prime the immune system for infection and coinfection. Additionally, increased levels of performance-focused Bacillus strains allow regulation of inflammatory responses, helping to prevent energy wastage.
New Insights on Cow Health, Transition Stress, and HPAI Coinfections from PathKinex™
Through PathKinex™ surveillance, we found that dairies sampled after highly pathogenic avian influenza (HPAI) outbreaks harbored higher levels of E. coli, Salmonella, and C. perfringens than unaffected herds. This core group of pathogens that flourish during periods of disease challenge can have significant consequences on immune status and feed intake.
Spotlight on Bacillus DFMs for Biogas Production in Livestock Waste Management
Large cattle and swine producers are increasingly adopting biogas capture systems to treat wastewater from livestock systems. Bacillus have broad hydrolysis capabilities with the potential to efficiently break down fiber in waste and allow downstream conversion into methane. In an in vitro methane capture system, Amnil® treatment consistently improved methane yield, ranging from 20%–40% greater production than controls.
A “Not-So-PathKinex™” Update: Spotlight on Environmental Benefits of Bacillus
Odor originating from livestock production systems is a common public concern that can lead to complaints and problems for the producer. Amnil® (DFM PAK® in the US) can help lessen challenges inside the barn and beyond by reducing production of odor compounds and improving manure composition.
Product Update: Highlighting ProVent® ECL with E. coli Challenge Models
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C. perfringens 101 and its Role in Coinfections
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Go Digital! Introduction to a New, Interactive PathKinex™ Report
As part of our continued commitment to innovation and client success, we have upgraded our PathKinex™ reports to help users explore their data more efficiently from anywhere and extract meaningful insights faster. The redesigned report introduces a suite of new features, including interactive figures, streamlined navigation, and mobile-friendly layouts, while preserving our foundational graphs like the AST heatmaps.
Looking Ahead
Thanks for following along with PathKinex™ this year. We are excited to keep delivering new microbial insights for animal health in 2026!
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